Delaware Street Drug Report
2025 Annual Report
Report Number: 2026-09
Executive Summary
The Overdose Response Center successfully tested 870 samples during 2025, detecting 50 individual compounds. The most commonly detected illicit drug was fentanyl, found in 65.6% of all samples. The most frequent sample type was a drug bag (294 samples). The highest monthly testing volume occurred in May with 127 samples. The most common compound combination was cocaine only (15% of all samples). Sixty percent of samples were linked to an identifiable stamp. The most frequently tested stamp was ‘Hey Yes’ with 34 samples. Among identified stamps, the most common compound combination was fentanyl, medetomidine, and tetracaine. The average monthly sample size was 72.5 and the median monthly sample size was 85.
Disclaimer
Street Drug Reports are intended for risk mitigation and educational purposes only and should not be used for professional or publication purposes. The data comes from sporadic drug residue testing conducted across locations in Delaware and should not be overgeneralized. Stamp names are not universal or consistent in the street supply and are provided for reference only. Testing identifies whether a compound is present (qualitative testing) and does not measure the amount of that compound within a sample (quantitative testing). Sample sizes varied by month.
Delaware Street Drug Report – 2025 Annual Report
Page 2: Sample Location and Type Breakdown
Contact Information
Contact: ORC@delaware.gov
Approved: 30 April 2026
Total Samples by County
| County | Sample Count | Percent |
| New Castle County | 351 | 40% |
| Kent County | 177 | 20% |
| Sussex County | 181 | 21% |
| Unknown | 19% |
Types of Samples Collected
Bag: 294
Syringe: 253
Pipe/Chore: 144
Unknown: 144
Other: 26
Powder: 3
Cooker: 2
Capsule: 1
Pill or Tablet: 1
Straw: 1
Total Samples per Month
| Month | Samples |
| January | 12 |
| February | 13 |
| March | 106 |
| April | 92 |
| May | 127 |
| June | 108 |
| July | 100 |
| August | 89 |
| September | 53 |
| October | 54 |
| November | 81 |
| December | 35 |
Page 3: Substances Detected
Contact: ORC@delaware.gov
Approved: 30 April 2026
Overview
From all 870 samples during 2025, the Overdose Response Center detected 50 unique compounds, with an average of 3.6 compounds detected per sample.
Most Common Illicit Drugs Detected
| Compound | Count | % of Total |
| Fentanyl | 571 | 65.6% |
| 4-ANPP | 245 | 28.2% |
| Cocaine | 229 | 26.3% |
| Methamphetamine | 89 | 10.2% |
| Heroin | 82 | 9.4% |
| 6-Monoacetylmorphine | 34 | 3.9% |
| N,N-Dimethylamphetamine | 16 | 1.8% |
Most Common Adulterants Detected
| Compound | Count | % of Total |
| Medetomidine | 447 | 51.4% |
| Tetracaine | 345 | 39.7% |
| Procaine | 202 | 23.2% |
| Lidocaine | 164 | 18.9% |
| Xylazine | 130 | 14.9% |
| Caffeine | 84 | 9.7% |
| Mannitol | 84 | 9.7% |
Additional Compounds Detected
| Compound | Count | % of Total |
| Benzoylecgonine | 15 | 1.7% |
| Ethyl 4-ANPP | 9 | 1.0% |
| Methylecgonine | 7 | 0.8% |
| Fluorofentanyl | 4 | 0.5% |
| Phenethyl 4-ANPP | 4 | 0.5% |
| Methyl Fentanyl | 3 | 0.3% |
| Despropionyl Methylfentanyl | 2 | 0.2% |
Additional Adulterants Detected
| Compound | Count | % of Total |
| Acetaminophen | 79 | 9.1% |
| BTMPS | 68 | 7.8% |
| Quinine | 36 | 4.1% |
| Pregabalin | 35 | 4.0% |
| Phenacetin | 30 | 3.4% |
| Diphenhydramine | 17 | 2.0% |
| Levamisole | 6 | 0.7% |
Page 4: Compound Combinations and Substance Highlights
Contact: ORC@delaware.gov
Approved: 30 April 2026
Most Common Compound Combinations
| Combination | Percent | Count |
| Cocaine Only | 15% | 129 |
| 4-ANPP, Fentanyl, Medetomidine | 9% | 78 |
| Fentanyl, Medetomidine, Tetracaine | 8% | 73 |
| Methamphetamine Only | 5% | 47 |
| Fentanyl, Medetomidine, Procaine | 5% | 43 |
| 4-ANPP, Caffeine, Fentanyl | 4% | 31 |
| 4-ANPP, Cocaine, Fentanyl | 2% | 17 |
| BTMPS, Fentanyl, Medetomidine | 2% | 17 |
| Fentanyl, Lidocaine, Medetomidine | 2% | 16 |
| 4-ANPP, Fentanyl, Mannitol | 2% | 15 |
2025 Substance Highlights
- Local anesthetics (Tetracaine, Procaine, or Lidocaine) – 97%
- Medetomidine – 59%
- Tetracaine – 44%
- Cocaine – 33%
- BTMPS – 11%
- Methamphetamine – 11%
- Pregabalin – 5%
- Quinine – 4%
- N,N-Dimethylamphetamine – 2%
- Dextromethorphan – 1%
- Levamisole – 1%
- Ortho-Fluorofentanyl – 1%
Newly Identified Compounds by Month
| Month | Newly Identified Compounds |
| January 2025 | Dextromethorphan |
| February 2025 | Pregabalin |
| March 2025 | Buprenorphine; Methylecgonine; Nicotinamide; Nicotine; N,N-Dimethylamphetamine |
| April 2025 | Ketamine; Benzocaine; Methyl Fentanyl |
| May 2025 | Methylecgonidine; Oleamide |
| June 2025 | Tetrahydrocannabinol (THC) |
| August 2025 | Papaverine |
| November 2025 | Melatonin |
Page 5: Most Frequently Tested Stamps
Contact: ORC@delaware.gov
Approved: 30 April 2026
The selected stamps below were the most frequently tested in 2025 along with their most common compound combination. Overall, the most common combination among these stamps was Fentanyl, Medetomidine, and Tetracaine (13% across all samples). Compounds may vary even among samples with the same stamp name.
| Stamp (# Samples) | Consistency | Most Common Compounds Detected | Notes |
| Hey Yes (34) | 32% | 4-ANPP, Fentanyl, Medetomidine, Pregabalin | |
| Get Hooked (20) | 37% | Fentanyl, Medetomidine, Tetracaine | |
| Gucci (19) | 58% | Fentanyl, Medetomidine, Tetracaine | |
| Boss Man (16) | 13% | Caffeine, Fentanyl, Heroin, Lidocaine | |
| NFL (16) | 6% | 4-ANPP, Caffeine, Fentanyl, Heroin, Lidocaine, Medetomidine, Procaine | |
| The Arrow (15) | 36% | 4-ANPP, Fentanyl, Medetomidine, Pregabalin | |
| Sexy (14) | 21% | 4-ANPP, Fentanyl, Medetomidine, Tetracaine | |
| Mr. Beast (11) | 45% | 4-ANPP, Caffeine, Fentanyl, Medetomidine, Xylazine | |
| 700 (9) | 33% | Fentanyl, Medetomidine, Procaine, Tetracaine | |
| Blue Magic (9) | 18% | 4-ANPP, Acetaminophen, Fentanyl, Lidocaine, Medetomidine, Procaine | Text truncated in source PDF after Procaine. |
| Goya (9) | 33% | Fentanyl, Medetomidine, Tetracaine | |
| Joker (9) | 22% | 4-ANPP, Fentanyl, Heroin, Medetomidine, Phenacetin, Procaine, Tetracaine | |
| Great Value (8) | 38% | 4-ANPP, Diphenhydramine, Fentanyl, Medetomidine, Tetracaine | |
| Homerun (8) | 38% | 4-ANPP, Fentanyl, Quinine | |
| Arrow (7) | 22% | 4-ANPP, Fentanyl, Medetomidine, Pregabalin |
Page 6: Street Drug Trends Over Time
Contact: ORC@delaware.gov
Approved: 30 April 2026
Narrative Summary
- Fentanyl consistently had the highest detection percentage throughout the year. Detection declined slightly during spring and early summer before peaking in September.
- Medetomidine started the year at similarly high levels to fentanyl, then declined and stabilized at an average detection rate of approximately 57% for the remainder of the year.
- Cocaine began the year at lower levels, increased rapidly to a peak in April, and then remained relatively stable at an average detection rate of about 33%.
- Xylazine showed moderate variability, increased briefly during the spring, and generally trended downward, ending December at its lowest detection rate of 2025.
- Methamphetamine was not detected at the beginning of the year, peaked in May, and then stabilized at an average detection rate of approximately 10%.
Trend Summary Table
| Substance | Start | Peak | End | Overall Trend |
| Xylazine | 25% | 33% | 6% | Decreasing |
| Fentanyl | 83% | 92% | 69% | Decreasing |
| Medetomidine | 83% | 92% | 60% | Decreasing |
| Cocaine | 17% | 43% | 31% | Increasing |
| Methamphetamine | 0% | 31% | 11% | Increasing |
Monthly Sample Sizes
N = 870 total samples. Monthly sample counts shown in the original chart: January 12, February 13, March 106, April 92, May 127, June 108, July 100, August 89, September 53, October 54, November 81, December 35.
Accessibility Note
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